2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel
  5. Sodium Channel Agonist

Sodium Channel Agonist

Sodium Channel Isoform Comparison

Sodium Channel Agonists (7):

Cat. No. Product Name Effect Purity
  • HY-131615
    TPC2-A1-P
    		Agonist 99.76%
    TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.
  • HY-N6868
    Dimethyl lithospermate B
    		Agonist 98.85%
    Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP).
  • HY-P5807A
    Cn2 toxin TFA
    		Agonist 98.13%
    Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6.
  • HY-P5172
    MitTx-alpha
    		Agonist
    MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels.
  • HY-P5784
    δ-Buthitoxin-Hj1a
    		Agonist
    δ-Buthitoxin-Hj1a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 17nM. δ-Buthitoxin-Hj1a can be used for the Dravet syndrome (DS) research.
  • HY-P5783
    δ-Buthitoxin-Hj2a
    		Agonist
    δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research.
  • HY-N12093
    Cevadine
    		Agonist
    Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity.